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Amendment 4 would require any constitutional amendment put on the ballot through the initiative petition process to pass in all eight congressional districts.
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Among the legislation the governor signed is a wide-reaching public health bill that expands access to birth control and requires the state to track cases of Lyme disease and alpha-gal syndrome.
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A Kansas City judge last week overturned a requirement that patients take the medication while a doctor is present.
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Medication abortion will be available in Missouri for the first time since 2018 after a judge determined most of the state's challenged abortion regulations are unconstitutional, including laws requiring hospital privileges, complication plans and special clinic licenses.
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Missouri Attorney General Catherine Hanaway was the lead Republican attorney general behind the letter. Sent on Hanaway's office letterhead, the attorneys general state that "the upsurge in home-setting chemical abortions has serious implications for the Safe Drinking Water Act."
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Another measure to be decided during the August primary is a proposal to require constitutional amendments put before voters through the initiative petition process to pass in all eight congressional districts.
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Proponents of the bill say the legislation is necessary to protect those who survive an attempted abortion, while opponents say it creates a hostile environment for medical workers.
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Poll directors said data indicates voters' views on transgender care for minors are a strong indicator of whether they would support the measure, which would effectively overturn a pro-abortion rights amendment from two years ago.
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U.S. Sens. Josh Hawley and Eric Schmitt expect Missouri Republican-backed ballot issues will succeed even in a tough election year.
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In addition to approving legislation that would allow students to transfer outside their district, senators sparred over bills on abortion education and preventing teachers from recognizing a student's preferred gender.