The Missouri State Highway Patrol reports Interstate 29 is shut down between Oregon and Mound City following a crash involving hazardous materials.
A post on the MSHP's Troop H X/Twitter account also says the crash resulted in injuries.
The Missouri Department of Transportation (MoDOT) says motorists are being routed off the interstate to Highway 59.
Click HERE to be directed to MoDOT's road condition website to check if I-29 remains closed.